Treatment of Cirrhosis-Associated Hyponatremia with Midodrine and Octreotide
نویسندگان
چکیده
منابع مشابه
Treatment of Cirrhosis-Associated Hyponatremia with Midodrine and Octreotide
BACKGROUND Hyponatremia in the setting of cirrhosis is a common electrolyte disorder with few therapeutic options. The free water retention is due to non-osmotic vasopressin secretion resulting from the cirrhosis-associated splanchnic vasodilatation. Therefore, vasoconstrictive therapy may correct this electrolyte abnormality. The aim of this study was to assess the efficacy of midodrine and oc...
متن کاملSystemic hemodynamic and renal effects of midodrine and octreotide in cirrhotic patients with ascites
e read with great interest the article by Minakari et al. regarding the effects of treatment with subcutaneous octreotide and oral midodrine in cirrhotic patients with ascites who continued to receive their standard diuretic treatment1 and we would like to comment on their results. First, the administration of midodrine for 3 days caused a non-significant increase in mean arterial pressure (MAP...
متن کاملHyponatremia: clinical associations, prognosis, and treatment in cirrhosis.
Hyponatremia has long been associated with worsened clinical outcomes in patients with cirrhosis and those awaiting liver transplant. However, in the last several years, new modalities of therapy, particularly aquaretics known as "vaptans," and comprehensive prognostic models have been increasingly studied in the hopes of bolstering serum sodium levels and altering liver transplant candidate st...
متن کاملDefining the role of albumin infusion in cirrhosis-associated hyponatremia.
The presence of negatively charged, impermeant proteins in the plasma space alters the distribution of diffusible ions in the plasma and interstitial fluid (ISF) compartments to preserve electroneutrality and is known as Gibbs-Donnan equilibrium. In patients with hypoalbuminemia due to underlying cirrhosis, the decrease in the plasma water albumin concentration ([Alb-]pw) would be expected to r...
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ژورنال
عنوان ژورنال: Frontiers in Medicine
سال: 2017
ISSN: 2296-858X
DOI: 10.3389/fmed.2017.00017